What are my risks of developing Alzheimer’s if I have the APOE e4 high risk version of the gene?

Individuals who test positive for one copy of the APOE e4 allele have 3X increased risk of developing late-onset Alzheimer’s disease compared to an individual who has tested negative for APOE e4. Individuals who test positive for two copies of the APOE e4 allele have a 10 – 15X increased risk of developing late-onset Alzheimer’s disease compared to an individual who has tested negative for APOE e4.